Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing

• Wound dressing with Janus superhydrophilic/superhydrophobic feature is designed. Superhydrophilic PCL-Gelatin fibers act as a pump-like suction layer. Suprehydrophobic side shows excellent anti-adhesion effect. Rational design of new wound materials aims to accelerate healing. Traditional hydrophilic dressings, however, tend cause retention exudate retention, which increases the risk bacterial infection, resulting in slower Herein, multifunctional amphiphilic nanofibrous superhydrophilic/ superhydrophobic designed In this design, top superhydrophilic polycaprolactone (PCL)-Gelatin (PCL-Gelatin, WCA ~ 0°) function layer that can effectively isolate from site, thereby providing drier condition lowers infection. More importantly, PCL-poly(perfluorodecyl methacrylate)- block -poly(dimethylsiloxane)- -poly(perfluorodecyl methacrylate) (PFMA- b -PDMS- -PFMA) (PCL-PFMA, 140°) contact site showed effect bacterial, cells and tissues, further lowering infection preventing secondary injuries caused by changes. Sprague-Dawley (SD) rat skin lesion model demonstrated significant improvement healing amphipathic / PCL-PFMA fiber films compared conventional hydrophilic- hydrophobic-only materials. After 14 days treatment, area group was close 100%. To best our acknowledge, pioneer exploration unidirectional drainage anti-adhesive ability, may have great potential for real life usage on clinical patients.